Action at Level 3: immunomodulation

Action at Level 3: immunomodulation

The immune system consists of several interdependent cells that collectively protect the body against the aggression of pathogenic microorganisms, parasites and viruses. The intestinal microflora plays an important role in the correct function of the immune system and the research carried out in this respect has shown that probiotics can modulate this aspect.

It is known that probiotics can act on the immune system of the host by signals sent from the intestinal lumen by dendritic cells, which stimulate CD4+ T cells that can lead to different populations of regulatory T cells (Treg).

Regulatory T cells are the main elements in maintaining the balance between the two populations of T helper (Th1/Th2) and, also, are responsible for maintaining the homeostasis of the immune system by secretion of IL-10.

In this regard, is important to say that all the strains present in Megaflora 9 evo have demonstrated its ability to interact with the immune system. Some of them stand out for their capacity to increase the production of IL-10, a regulatory and anti-inflammatory cytokine.

Example of mechanism regulating the host immunity by Lactobacillus plantarum W1 through interaction of dendritic cells.

Next graph shows the induction of IL-10 by different strains of Megaflora 9 evo in the presence of peripheral mononuclear blood cells. From the different tested strains, Lactobacillus plantarum W21, L. acidophilus W22 and Enterococcus faecium W54, were those that presented a higher degree of stimulation, being E. faecium W54 the strain with the greatest potential in stimulating the production of IL-10.

Production of IL-10 in a culture of peripheral mononuclear blood cells in presence of different strains present in Megaflora 9 evo (Lactococcus lactis W19, L. paracasei W20, L. plantarum W21, L. acidophilus W22 and Enterococcus faecium W54).

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