{"id":3539,"date":"2018-08-27T07:56:46","date_gmt":"2018-08-27T07:56:46","guid":{"rendered":"http:\/\/www.megaflora9.com\/wp\/?p=3539"},"modified":"2018-09-26T05:57:43","modified_gmt":"2018-09-26T05:57:43","slug":"action-at-level-3-immunomodulation","status":"publish","type":"post","link":"https:\/\/megaflora9.com\/?p=3539","title":{"rendered":"Action at Level 3: immunomodulation"},"content":{"rendered":"<p>The immune system consists of several interdependent\u00a0cells that collectively protect the body against the aggression\u00a0of pathogenic microorganisms, parasites and\u00a0viruses. The intestinal microflora plays an important role\u00a0in the correct function of the immune system and the\u00a0research carried out in this respect has shown that probiotics\u00a0can modulate this aspect.<\/p>\n<p>It is known that probiotics can act on the immune system\u00a0of the host by signals sent from the intestinal lumen\u00a0by dendritic cells, which stimulate CD4+ T cells\u00a0that can lead to different populations of regulatory T\u00a0cells (Treg).<\/p>\n<p>Regulatory T cells are the main elements in maintaining\u00a0the balance between the two populations of T helper\u00a0(Th1\/Th2) and, also, are responsible for maintaining\u00a0the homeostasis of the immune system by secretion of\u00a0IL-10.<\/p>\n<p>In this regard, is important to say that all the strains present\u00a0in <strong>Megaflora 9 evo<\/strong> have demonstrated its ability\u00a0to interact with the immune system. Some of them stand\u00a0out for their capacity to increase the production of IL-10,\u00a0a regulatory and anti-inflammatory cytokine.<\/p>\n<div id=\"attachment_3416\" style=\"width: 510px\" class=\"wp-caption aligncenter\"><img aria-describedby=\"caption-attachment-3416\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-3416\" src=\"http:\/\/www.megaflora9.com\/wp\/wp-content\/uploads\/2018\/08\/ACTION-4.jpg\" alt=\"\" width=\"500\" height=\"558\" srcset=\"https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-4.jpg 899w, https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-4-269x300.jpg 269w, https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-4-768x858.jpg 768w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><p id=\"caption-attachment-3416\" class=\"wp-caption-text\">Example of mechanism regulating the\u00a0host immunity by <em>Lactobacillus plantarum<\/em> W1 through\u00a0interaction of dendritic cells.<\/p><\/div>\n<p>Next graph shows the induction of IL-10 by different\u00a0strains of <strong>Megaflora 9 evo<\/strong> in the presence of peripheral\u00a0mononuclear blood cells. From the different tested\u00a0strains, <em>Lactobacillus plantarum<\/em> W21, <em>L. acidophilus<\/em> W22\u00a0and <em>Enterococcus faecium<\/em> W54, were those that presented\u00a0a higher degree of stimulation, being <em>E. faecium<\/em> W54\u00a0the strain with the greatest potential in stimulating the\u00a0production of IL-10.<\/p>\n<div id=\"attachment_3417\" style=\"width: 610px\" class=\"wp-caption aligncenter\"><img aria-describedby=\"caption-attachment-3417\" decoding=\"async\" loading=\"lazy\" class=\"wp-image-3417\" src=\"http:\/\/www.megaflora9.com\/wp\/wp-content\/uploads\/2018\/08\/ACTION-5-1024x856.jpg\" alt=\"\" width=\"600\" height=\"501\" srcset=\"https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-5-1024x856.jpg 1024w, https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-5-300x251.jpg 300w, https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-5-768x642.jpg 768w, https:\/\/megaflora9.com\/wp-content\/uploads\/2018\/08\/ACTION-5.jpg 1100w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><p id=\"caption-attachment-3417\" class=\"wp-caption-text\">Production of IL-10 in a culture of peripheral mononuclear\u00a0blood cells in presence of different strains present\u00a0in <strong>Megaflora 9 evo<\/strong> (<em>Lactococcus lactis<\/em> W19,<em> L. paracasei\u00a0<\/em>W20, <em>L. plantarum<\/em> W21,<em> L. acidophilus<\/em> W22 and <em>Enterococcus\u00a0faecium<\/em> W54).<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<div class=\"slide-text-bg2\"><span>The immune system consists of several interdependent\u00a0cells that collectively protect the body against the aggression\u00a0of pathogenic microorganisms, parasi<\/span><\/div>\n<div class=\"slide-btn-area-sm\"><a href=\"https:\/\/megaflora9.com\/?p=3539\" class=\"slide-btn-sm\">Read More<\/a><\/div>\n","protected":false},"author":3,"featured_media":3418,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/posts\/3539"}],"collection":[{"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/megaflora9.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3539"}],"version-history":[{"count":3,"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/posts\/3539\/revisions"}],"predecessor-version":[{"id":3566,"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/posts\/3539\/revisions\/3566"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/megaflora9.com\/index.php?rest_route=\/wp\/v2\/media\/3418"}],"wp:attachment":[{"href":"https:\/\/megaflora9.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3539"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/megaflora9.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3539"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/megaflora9.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3539"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}