{"id":3402,"date":"2018-08-22T09:19:16","date_gmt":"2018-08-22T09:19:16","guid":{"rendered":"http:\/\/www.megaflora9.com\/wp\/?p=3402"},"modified":"2018-09-26T06:28:59","modified_gmt":"2018-09-26T06:28:59","slug":"gastrointestinal-survival","status":"publish","type":"post","link":"https:\/\/megaflora9.com\/?p=3402","title":{"rendered":"Gastrointestinal survival"},"content":{"rendered":"

Surviving the path of the gastrointestinal tract is the first\u00a0basic function of a probiotic based product. The more\u00a0bacteria survive the passage through the gastrointestinal\u00a0tract, better will be the effect on our body.<\/p>\n

When bacteria are unprotected, a large number of viable\u00a0cells is destroyed as a result of the low pH of the stomach,\u00a0enzymes and digestive fluids.<\/p>\n

In traditional products based on probiotics, a large quantity\u00a0of bacteria are destroyed by the fluids of the GI tract.\u00a0It is estimated that the survival of the bacteria that are\u00a0ingested without any protection ranges from 0.5 to 1%,\u00a0when they reach the intestine, meaning that, for example,\u00a0from a concentration of 100,000 million bacteria\u00a0per gram of product supplied, only 1,000 million bacteria\u00a0will reach the intestine alive.<\/p>\n

Probiotic blend:<\/strong>\u00a0with 100.000 million bacteria\/g (1 x 1011<\/sup>)
\n1% de survival = 1.000 million viable bacteria (1 x 109<\/sup>)<\/p>\n

Megaflora 9 evo:\u00a0<\/strong>with 2.000 million bacteria\/g (2 x 109<\/sup>)
\nminimum 90% survival = more than 1.800 million viable bacteria\u00a0(>1,8 x 109<\/sup>)<\/p>\n

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The technology used in Megaflora 9 evo<\/strong> production\u00a0protects the bacteria against the acidic conditions of the\u00a0stomach and keeps bacteria alive. This technology ensures\u00a0a survival of more than the 90% of the initial concentration.\u00a0This explains why the concentration of bacteria\u00a0in Megaflora 9 evo<\/strong> does not need to be as high\u00a0as other commercial preparations, in which an important\u00a0part of the bacteria suffer a high mortality during their\u00a0transit through the GI passage.<\/p>\n

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In vitro<\/em> model that simulates the digestive system showing compartmentalisation, pH, enzyme and bile secretion\u00a0over 6 hours digestion.<\/p><\/div>\n

Gastrointestinal survival can be studied on a in vitro<\/em>\u00a0model developed by the University of Maastricht. This\u00a0model simulates the passage of bacteria through the GI\u00a0tract and allows to calculate the survival of the strains,\u00a0and its resistance to gastric acid, pepsin, pancreatin and\u00a0bile salts.<\/p>\n

The model imitates the compartmentalization and timing\u00a0of transit in every part of the GI tract, regulating the\u00a0secretion of pH, addition of enzymes and secretion of\u00a0bile onto the sample to be studied.<\/p>\n

The experiment is run at 37 \u00b0 C and the total count of bacteria\u00a0in the sample is measured at four different times:<\/p>\n